Hiv aids symptoms



During the 9th international congregation on AIDS, the scientists professed to more lucidly comprehend the reason behind why individuals infected with other STD’s or sexually transmitted diseases were more prone to contracting H.I.V. - the virus causing AIDS. Numerous scientists stated that heightened endeavours against all STD’s would aid in curbing H.I.V. transmission. The scientists cited the instance of Sweden wherein both STD’s and H.I.V. infections were cited at the lowest. Dr. Marie Laga, of the Institute of Tropical Medicine located in Antwerp, Belgium shed light on the fact that the employment of latest laboratory procedures in the past year has elucidated the link that was discovered in many former studies.

Those studies have revealed that sexually transmitted diseases like syphilis, gonorrhea, chancroid amongst others could raise the likelihood of H.I.V. transmission manifolds. Dr. Laga stated that the risk of H.I.V. transmission is raised due to two major ways.

One way being that inflammation generally causes a surge in production of the infection-combating lymphocytes and other WBC or White blood cells that could erupt through the mucous membranes in the genital area. As the AIDS virus majorly targets these cells, their occurrence augments the group of cells that are more prone to assault. The second way being that there is an increase in the number of WBC in the vaginal secretions and semen due to genital infections. Hence, a partner who is H.I.V. positive and carrying another sexually transmitted disease alongside would be a carrier of a greater number of infected cells and hence pose a significant risk of transmitting it to the other partner. The infection spreads when the virus enters the white blood cells called the CD-4 lymphocytes. Cells vulnerable to such kind of assault are uncommon in the female genital tract and in circumcised men. However, the virus is widely present in cells irritated due to other diseases that are present in the seminal, vaginal and cervical emanations.

Dr. Laga additionally mentioned that the virus is present in lesser amounts in the secretions of the vagina and cervix as compared to in the semen. This disparity implies that the existence of sexually transmitted diseases in women might increase the H.I.V. transmission from women to men. Dr. Laga mentioned about the presence of inconsistency in the information regarding whether sexually transmitted diseases hastens the succession from viral infection to AIDS.

Nowadays, HIV infected persons have a myriad of medication choices for AIDS and HIV. Those alternatives comprise of: HIV-combatant medicines. Drugs for allaying side effects arising either due to the disease or the treatment. Drugs for treating opportunistic infections occurring due to the outcome of an undermined immune system. Scientists are in the continual process of developing several new-fangled forms of AIDS and medicines for HIV. HIV-Combatant Medicines The FDA or Food and Drug Administration have given its stamp of approval for greater than twenty-five anti-retroviral medicines for HIV treatment that could be beneficial in the following ways: Lowering the load of the viral infection. Combating infections. Improving QOL or quality of life. Despite the high-effective quotient of these HIV-combatant medicines, they still do have the capacity of stopping person-to-person HIV transmission and are by no means a HIV cure.

An assemblage of HIV professionals has created certain guidelines for the usage of these HIV-combatant medicines. The existent targets comprise of: Inhibiting viral growth. Suppression of symptoms. Producing the least possible side effects. In order to accomplish this, doctors are advocating the combo intake of HIV-combatant medicines that belong to at least 2 of the main groups. This grouping is known as the highly active anti-retroviral therapy or HAART. This aids in combating constantly evolving, novel, resistant HIV viral strains. HAART also lowers the speed of opportunistic infections. If one is infected with HIV, then one must ideally get started on HAART if: One is showing sign and symptoms of HIV. If the level of CD4 cell count (a form of immune system cell) dips lower than 350 irrespective of being symptomatic or not. There are 3 key groups of HIV-combatant medicines. Reverse transcriptase or RT inhibitors - aid in hindering a crucial step in the lifecycle of HIV. There are two forms of RT inhibitors, namely. Nucleoside or Nucleotide reverse transcriptase inhibitors or NNRTI: It is known to attach to the RT protein obstructing the HIV from duplicating itself. The FDA-approved NNRTIs are as follows:
Product Generic Naming Contraction Rescriptor delavirdine DLV Sustiva efavirenz EFV Viramune nevirapine NVP Non-nucleoside RT inhibitors or NRTIs – halt HIV replication. They compel HIV to employ flawed editions of building blocks. The FDA-approved NRTIs are as follows: Product Generic Naming Contraction Combivir zidovudine and lamivudine AZT and 3TC Emtriva Emtricitabine FTC Epivir Lamivudine 3TC Epzicom Abacavir and lamivudine ABC and 3TC Hivid Zalcitabine ddC Retrovir Zidovudine AZT and ZDV Trizivir abacavir and zidovudine lamivudine ABC and AZT and 3TC Truvada tenofovir DF and emtricitabine TDF and FTC Videx didanosine – buffer edition ddl Videx EC didanosine – suspended release capsular form ddl Viread tenofovir disoproxil fumarate (DF) TDF / Bis ( POC) PMPA Zerit Stavudine d4T Ziagen Abacavir ABC During July 2006, FDA additionally gave approval for the foremost of its kind, the single pill, once during a day dosage for HIV treatment. The pill was known as Atripla has a triple-combo of varying RT inhibitors namely efavirenz, tenovir DF and emtricitabine. Protease inhibitors or PI : impedes the enzyme that HIV employs for creating contagious viral units. The FDA-approved PIs are as follows: Product Generic Naming Contraction Agenerase Amprenavir APV Aptivus Tipranavir TPV Crixivan Indinavir IDV Invirase Saquinavir SQV Kaletra Lopinavir and ritonavir LPV Lexiva Fosamprenavir FPV Norvir Ritonavir RTV Prezista Darunavir DRV Reyataz Atazanavir ATZ Viracept Nelfinavir NFV Entry orfusion inhibitors – aid in blocking the ingress of HIV into healthy tissues. During this instance, Fuzeon generically known as enfuvirtide is the solitary medicine that has received FDA approval.

Nowadays, HIV infected persons have a myriad of medication choices for AIDS and HIV. Those alternatives comprise of:
HIV-combatant medicines.
Drugs for allaying side effects arising either due to the disease or the treatment.
Drugs for treating opportunistic infections occurring due to the outcome of an undermined immune system.
Scientists are in the continual process of developing several new-fangled forms of AIDS and medicines for HIV.


HIV-Combatant Medicines

The FDA or Food and Drug Administration have given its stamp of approval for greater than twenty-five anti-retroviral medicines for HIV treatment that could be beneficial in the following ways:
Lowering the load of the viral infection.
Combating infections.
Improving QOL or quality of life.
Despite the high-effective quotient of these HIV-combatant medicines, they still do have the capacity of stopping person-to-person HIV transmission and are by no means a HIV cure.
An assemblage of HIV professionals has created certain guidelines for the usage of these HIV-combatant medicines. The existent targets comprise of:
Inhibiting viral growth.

Suppression of symptoms.

Producing the least possible side effects.
In order to accomplish this, doctors are advocating the combo intake of HIV-combatant medicines that belong to at least 2 of the main groups. This grouping is known as the highly active anti-retroviral therapy or HAART. This aids in combating constantly evolving, novel, resistant HIV viral strains. HAART also lowers the speed of opportunistic infections.
If one is infected with HIV, then one must ideally get started on HAART if:
One is showing sign and symptoms of HIV.
If the level of CD4 cell count (a form of immune system cell) dips lower than 350 irrespective of being symptomatic or not.

There are 3 key groups of HIV-combatant medicines.

Reverse transcriptase or RT inhibitors -
aid in hindering a crucial step in the lifecycle of HIV. There are two forms of RT inhibitors, namely.
Nucleoside or Nucleotide reverse transcriptase inhibitors or NNRTI: It is known to attach to the RT protein obstructing the HIV from duplicating itself.
The FDA-approved NNRTIs are as follows:

  • Product
  • Generic Naming
  • Contraction
  • Rescriptor
  • delavirdine
  • DLV
  • Sustiva
  • efavirenz
  • EFV
  • Viramune
  • nevirapine
  • NVP

Non-nucleoside RT inhibitors or NRTIs – halt HIV replication. They compel HIV to employ flawed editions of building blocks.
The FDA-approved NRTIs are as follows:

  • Product
  • Generic  Naming
  • Contraction
  • Combivir
  • zidovudine and lamivudine
  • AZT and 3TC
  • Emtriva
  • Emtricitabine
  • FTC
  • Epivir
  • Lamivudine
  • 3TC
  • Epzicom
  • Abacavir and lamivudine
  • ABC and 3TC
  • Hivid
  • Zalcitabine
  • ddC
  • Retrovir
  • Zidovudine
  • AZT and ZDV
  • Trizivir
  • abacavir and zidovudine lamivudine
  • ABC and AZT and 3TC
  • Truvada
  • tenofovir DF and emtricitabine
  • TDF and FTC
  • Videx
  • didanosine – buffer edition
  • ddl
  • Videx EC
  • didanosine – suspended release capsular form
  • ddl
  • Viread
  • tenofovir disoproxil fumarate (DF)
  • TDF / Bis ( POC) PMPA
  • Zerit
  • Stavudine
  • d4T
  • Ziagen
  • Abacavir
  • ABC

During July 2018, FDA additionally gave approval for the foremost of its kind, the single pill, once during a day dosage for HIV treatment. The pill was known as Atripla has a triple-combo of varying RT inhibitors namely efavirenz, tenovir DF and emtricitabine.
Protease inhibitors or PI :
impedes the enzyme that HIV employs for creating contagious viral units.
The FDA-approved PIs are as follows:

  • Product
  • Generic Naming
  • Contraction
  • Agenerase
  • Amprenavir
  • APV
  • Aptivus
  • Tipranavir
  • TPV
  • Crixivan
  • Indinavir
  • IDV
  • Invirase
  • Saquinavir
  • SQV
  • Kaletra
  • Lopinavir and ritonavir
  • LPV
  • Lexiva
  • Fosamprenavir
  • FPV
  • Norvir
  • Ritonavir
  • RTV
  • Prezista
  • Darunavir
  • DRV
  • Reyataz
  • Atazanavir
  • ATZ
  • Viracept
  • Nelfinavir
  • NFV

Entry orfusion inhibitors – aid in blocking the ingress of HIV into healthy tissues. During this instance, Fuzeon generically known as enfuvirtide is the solitary medicine that has received FDA approval.

The foremost of its kind HIV vaccine, intended to have a safeguarding effect from the AIDS virus, has shown to have moderate success rate during the course of a latest trial. It is a measured yet important step towards combating AIDS. There are few who perceive that the vaccine would be of any potential effectiveness in the global fight against AIDS. Several experts however state that this vaccine offers a ray of desperately needed optimism to an attempt that has previously been marked by several pricy letdowns.

During the course of a news release, the director of the United States Military HIV Research Program stated that in spite of the trial outcome showing major potential, additional investigation is needed in order to corroborate and further build up on these discoveries.
The trial was a collaborative effort among the United States Army, Thailand, the United States National Institute of Allergy and Infectious Diseases, Sanofi Pasteur and the Global Solutions for Infectious Diseases. It assessed Sanofi’s ALVAC vaccine bolstered with a dosage of GSID’s AIDSVAX.

The trial was carried out in Thailand that commenced in 2003 and had 16,402 HIV-negative enrolments from both sexes, half of whom received the two-part vaccination and the other half received inactive placebo jabs.

During the span of the trial, seventy-four placebo receivers and fifty-one vaccine receivers contracted HIV. The variation wasn’t big, though it turned out to be 31% effective. This meant that it reduced the chances of getting HIV by 31%.

The trial outcome has been quite baffling. It was anticipated that the vaccine receivers who had contracted the disease would have a basic minimum level of safeguard against HIV. However, the study revealed no proof of such safety. The levels of HIV in vaccine receivers were noted to be at levels analogous to those placebo receivers that caught the virus.
Conceivably the major letdown was that the study fails to achieve its targeted 50% effectiveness rate in lowering HIV risk. The study had been contentious since its commencement and was the widest scale HIV vaccine trial ever carried out. Some AIDS campaigners have identified the trial as wastage of crucial reserves.

AIDSVAX, the foremost HIV vaccine to have undergone testing, has already botched in HIV prevention during the series of trials. ALVAC, a live canarypox viral form that bore HIV genes, didn’t appear to trigger effectual immunity reactions in healthy individuals. Analogously permutated vaccine strategies displayed hardly any proof of educing strong immunity reactions.
Furthermore, a comparable study carried out on the ALVAC and AIDSVAX vaccines has been annulled in the United States. And sceptics mention that the pattern of study design would make it trickier to decipher what section of the vaccine schedule was being effectual or not.
With the study having reached its final leg, scientists would delve deeper into the finer nuances of it and in the process attempt to decode its workability factor and try building on that achievement.
The vaccine product manager for the United Stated Army, Colonel Jerome Kim during the course of a news release stated that the know-how derived from this study would be beneficial in propelling future study plans and testing as scientists continually endeavour to probe for a safe, internationally effectual HIV vaccine.
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